Preinstalled Apps can be “uninstalled” via ADB … Uninstall default apps - #29 by AnotherElk … which technically is kind of a disabling, but much more than the disabling you can easily do in the App settings. It survives OS updates, for instance.
Really removing as far as I see would require you to build your own /e/OS and just leave the stuff out which you don’t want in it … https://doc.e.foundation/support-topics/build-e, but it’s possible I’m missing something.