E2EE thoughts, ideas, questions

Dear /e/-community,
if Murena and /e/OS were to advance its encryption for its cloud services further to be end-to-end (E2EE), what do you think would be important to keep in mind, in terms of features, potential challenges etc? And how could such a solution maintain a smooth UX for mainstream users, while at the same time providing the maximum security of E2EE?
Any ideas and thoughts welcome!

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