Same here.
Since upgrading to 1.5.1-s (2 Nov 2022) on my FP4 some apps won’t work with wifi (like AntennaPod, Fennec, /e/ Updater) until I reboot the device. After some time they stop working again and I have to reboot.
Plus, private DNS won’t work at all, see my findings at my other post https://community.e.foundation/t/encrypt-your-dns-queries-on-e-os-system-wide/16252/24?u=vic.fontaine