With /e/OS 4.1 a new Passwords app with encryption was introduced.
From very recent (including today) murena-passwords threads some users find some difficulties to start. Worked ok for me, knowing that I was effectively starting a new and different app
Edit from the above docs link we see
On Murena Workspace , this is where /e/OS’s account integration matters: the very first time Passwords is signed in, /e/OS notices encryption isn’t set up yet and walks you through it automatically, with the steps below. You won’t see them again afterwards.
You won’t see them again afterwards.
Suggests, if in difficulties, one should ensure Password Sync is ON (and recently synced) in Settings > Accounts.