For me it was not an e/OS Problem. I am able to Connect via my mobile connection but not via the local WLAN (in the hotel) because the local WLAN uses IPv4 only and at home i have only IPv6. To connect with my mobile connection i had to change my APN Settings to IPv4/IPv6, it was IPv4 only for my eSIM. After that i was able to get the Wireguard connection. Don’t know if this helps for your case but could be a gold idea to check.