OK for my Pixel5 (purchased in /e/-shop) not rooted. It was upgraded with 1.21-t stable release (updated from 1.20 to 1.21 (1.21-t-20240323388918-stable-redfin) - e_redfin-user 13 TQ3A.230901.001 eng.root.20240323.064917 dev-keys).
To be noted : upgrade to e-1.21-t-stable take a lot of time but less as in 1.20 upgrade.
Also, 2 reboots were needed before internet access can work correctly (wifi or data). Some applications could access it while others (la banque postale) could not at the first boot.
UPDATE : It seems that the battery drains more quickly (5-10 % during night without wifi/data on nor app loaded).
Another thing : the wifi always comes ans goes. 
UPDATE 2 (04/15/2024): when I use the camera, in addition to the pbm noted below, the battery drains extremely quickly and the phone seems very hot (I also got a message from alert on this subject!).
The screen saver always comes back after a few seconds even though I uncheck it.
As for previous releases, all functions seems to be OK.
!! The camera pbm (described here or there ) still remains : when I take a picture with lens1 the final picture is blurry when I’m not in “auto” mode.
It never append when I received my phone from Murena.
When I use another camera app there is not such a problem.